This Article First Published on January 28, doi: Related Content Load related web page information. View this article with LENS. Responses Submit a Letter to the Editor. To whom correspondence may be addressed:
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Journal of Lipid Research. In support of this notion, we showed that DLK expression was restricted to the granular layer in situ.
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In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum.
To whom correspondence may be addressed: Abstract In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum. Articles by Germain, L. Submit your work to JBC. This Article First Published on January 28, doi: Google Scholar Articles by Robitaille, H.
Responses Submit a Letter to the Dpk. Search for related content. In addition, cultured keratinocytes infected with a recombinant adenovirus expressing DLK exhibited morphological and biochemical changes, including a suprabasal localization, altered cell shape, compacted cytoplasm, DNA fragmentation, and the up-regulation of filaggrin, that are reminiscent of a terminally differentiated phenotype.
You’ll be in good company. We now report that a single kinase, the mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase DLKacts in the epidermis to promote the terminal differentiation of human xlk.
Although it is expected that the last phases of this process must be tightly regulated since it results in cell death, the signaling pathways involved in this induction remain ill defined. View this article with LENS.
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Moreover the expression of wild-type DLK in keratinocytes stimulated transglutaminase activity and the consequent formation of the cornified cell envelope, while a kinase-inactive variant of DLK did not. Prev Next Table of Contents.
Classifications Mechanisms of Signal Transduction. Together these results identify DLK as a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification. Related Content Load related web page information.